loader image

Nature’s Intelligence™

It has long been recognized that the natural world contains a profusion of exciting therapeutic potential. The challenge, however, has been to identify molecules that can be converted into therapeutics. There has been considerable investment in developing platforms, yet they have generally been ineffective at producing multiple novel treatments.

This is largely due to toxicity – as each effort to discover a disease target and develop a molecule or compound that hits that target without causing toxicity elsewhere in the body is limited.

A First In Comparative Genomics

Comparative Genomics offers a different and wider approach to the quest for an effective platform, one capable of treating multiple diseases without causing toxicity. Extreme adaptability through evolution is widespread in many animals. This results in a wide pool of potential targets from which to rapidly develop novel treatments.

Using the versatility of contrast biology, comparative genomics enabled cellNUA to link animal proteome expression networks with human disease networks to identify shared pathways.

While arguably there is no one perfect animal model for human disease, the team began a deep dive into published genomic data and scientific literature, starting with mammalian and insects species.  The team refined the search, focussing on the honeybee and building upon the  Honeybee Genome sequencing Initiative, believing there was significant potential for ethical healthcare advancements.

A New Immunological Pathway

From all species in our review, the honeybee demonstrated evolved resistance towards many disease states threatening both the human and animal kingdoms. We realized there were many immune pathways and mechanisms unstudied in the hive, many of which with powerful protections against devastating human diseases. 

Because of the overlap between conserved areas and mutations associated in human disease, logically mammal models tend be preferred. But it is all about finding the proper model. The perfect model! A sustainable model that serves as a cruelty-free platform. 

Seeking to transform how we fight our most devastating diseases by unlocking the mechanisms of human immunity and expediting the development of new therapeutics, the cellNUA team merged Artificial Intelligence and Biomedicine. The team established the honeybees as the ideal candidate model for exploitation, given that hive molecules and compounds are nanomedicine by nature:

The most microscopic nanotechnology that you can find is in the bees!

Join the Movement

Be the first to know what’s happening